Jeffrey Hofmann, MD, PhD

Postdoctoral Fellow

My overall research interest is in the biological mechanisms of aging, and how this contributes to human disease. I began my scientific career as an undergraduate at Brown University ('08), where I majored in computational biology and studied mitochondrial evolution in Drosophila. I continued at Brown to do my MD ('16) and PhD ('14). In graduate school, I primarily studied a long-lived model of mice which are haploinsufficient for the gene Myc, and investigated what makes them live longer than wildtype mice. I came to UCSF in 2016 for residency in anatomic pathology, and then progressed into a fellowship in neuropathology in 2018. As a neuropathology fellow, I have been able to renew my research in aging by studying the aging brain and neurodegenerative diseases.  My current projects include characterizing the neurodegenerative effects of cell type-specific autophagy impairment in mice, investigating the interaction between C9orf72 and progranulin knockout genetic models of amyotrophic lateral sclerosis/frontotemporal dementia, and determining the amount and distribution of gliosis in limbic-predominant, age-related TDP-43 encephalopathy.

Past Awards and Fellowships:
F30 (NRSA) NIH Grant to study Wnt signaling in cellular senescence and aging (2009-14)