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Jeffrey Hofmann, MD, PhD

 

Sean P. Ferris, MD PhD

Jeffrey Hofmann, MD, PhD

Postdoctoral Fellow

My overall research interest is in the biological mechanisms of aging, and how this contributes to human disease. I began my scientific career as an undergraduate at Brown University ('08), where I majored in computational biology and studied mitochondrial evolution in Drosophila. I continued at Brown to do my MD ('16) and PhD ('14). In graduate school, I primarily studied a long-lived model of mice which are haploinsufficient for the gene Myc, and investigated what makes them live longer than wildtype mice. I came to UCSF in 2016 for residency in anatomic pathology, and then progressed into a fellowship in neuropathology in 2018. As a neuropathology fellow, I have been able to renew my research in aging by studying the aging brain and neurodegenerative diseases.  My current projects include characterizing the neurodegenerative effects of cell type-specific autophagy impairment in mice, investigating the interaction between C9orf72 and progranulin knockout genetic models of amyotrophic lateral sclerosis/frontotemporal dementia, and determining the amount and distribution of gliosis in limbic-predominant, age-related TDP-43 encephalopathy.

Past Awards and Fellowships:
F30 (NRSA) NIH Grant to study Wnt signaling in cellular senescence and aging (2009-14)